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|Title (ja): ||有機じん肺に関する研究|
|Title (en): ||STUDIES ON PNEUMOCONIOSIS CAUSED BY ORGANIC DUSTS|
|Authors (ja): ||阿部 彰|
|Authors (en): ||Akira ABE , M. D., D. M. Sc. & Takao ISHIKAWA|
|Authors (ja_kana): ||ｱﾍﾞ ｱｷﾗ|
|Authors etc: ||石川 孝夫|
|Authors etc (ja_kana): ||ｲｼｶﾜ ﾀｶｵ|
|Keywords: || |
|Issue Date: ||10-Jan-1967
|Total No.: ||0
|code A: ||7.4|
|numbe A: ||職業病・職業性障害 − じん肺|
|Abstract(en): ||Radiographical examinations and pulmonary function test were performed on workers exposed to palm-Flax, cotton-and bakelite dust. The air-borne dust concentration in their work places were also determined. Radiograms showed in some cases small opacities of puncti-form and linear ones. It was confirmed by animal experiments with rats that infusion of organic dust could cause dust foci in the lung.
(A) Air-borne dust concentration, radiographical findings and results of pulmonary function tests.
1) Dust concentration: Regarding a palm fibre processing factory, the dust concentration was highest at the spot of untwining (23 mg/m3). In case of a flax processing factory, the concentration was as high as 90 mg/m3 and 168 mg/m3 around the rug machine and the spinning machine respectively. A cotton carding factory showed so a high value as 268 mg/m3 at the spot of cotton opening. Air-borne dust in these factories was identified as vegetable fibres including fairly long particles.
2) Radiogram: Radiographical examinations and inquiries into symptoms of 20 palm workers, 24 flax workers and 8 cotton workers revealed no sign of allergic ailment such as byssinosis although radiograms presented small opacities of puncti-form (category 1 p~3 p) and linear opacities. No changes of hilar shadow could be found. If changes slighter than 1 p is expressed by a notation Rx, there were found 5 cases of Rx and 1 case of category 1 p in the palm factory, 5 cases of Rx and 1 case of 1 p in the flax factory and 4 cases of Rx, 2 cases of 1 p, 1 case of 2 p (after 9. 6 years of dust exposure) and 1 case of 3 p (after 27 years of dust exposure) in the cotton factory.
3) In the bakelite factory investigated, the dust concentration at the cutting machine was 10.5 mg/m3, but most particles mere comparatively large. Among 16 workers, there were found 4 cases of Rx, 3 cases of 1 p and 1 case of 2 p. Radiograms showed no changes of hilar shadow. Neither allergic symptoms nor signs of inflammatory complication were noticed except nasal symptoms in 4 cases and history of nasal diseases in4 cases. Nasal disorder as such seemed to be related with coarse size of particles.
4) Pulmonary function tests were performed on 16 cases showing Rx or more distinct radiographical findings. The tests revealed 5 cases of slight impairment and 1 case of moderate impairment (a cotton factory worker with 1 p of radiogram whose exposure to dust was as long as 16 years).
(B) Animal experiment.
1) Intratracheal infusions of 0.5 ml saline solution suspending dust were made, adopting rats as experimental animals. Dust of cotton, bakelite, nylon, cork, and Japanese cedar and wheat flour were used in the infusion. All sorts of above mentioned dust caused dust foci, most of which occupied one or several alveoli. In case of Japanese cedar dust, there was found granuloma as large as 0.5 mm in diameter. Fibrosis in the foci was weak in cases of cotton, cork and wheat flour, but remarkable in cases of resin and Japanese cedar.
2) Acute as well as chronic bronchitis was noticed in cases of wheat flour, cork and cedar. Especially, wheat flour caused sever bronchitis followed by emphysema and atelectasis.
3) Changes of hilar lymph-nodes were scarcely noted except localized proliferation of reticulum cells and aggregation of dusts in case of cotton, bakelite and cork.
4) The above-mentioned results of animal experiments suggest that various kinds of organic dust of natural or synthetic substance can cause dust foci of alveolar type in human lungs, and that pneumoconiosis due to dust of natural organic substances such as wheat flour, cedar and cork is inclined to be complicated with bronchial inflammation.
(C) General considerations on pneumoconiosis due to organic dust.
Radiographical findings of workers exposed to various sorts of organic dust and pathological findings of animal experiments suggest that dust of any organic substance, if it is hardly soluble or insoluble, can cause pneumoconiosis just as inorganic dust, and accordingly efforts should be made in prevention and care of pneumoconiosis in factories yielding organic dust. Moreover it should be kept in mined that pneumoconiosis due to some sorts of organic dust should be regarded as rather malignant because of frequent inflammatory complications.|
|Appears in Collections:||1961-70|
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