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Title (ja): じん肺組織内の粉じんに関する研究 第1報 大切片標本X線回折法について
Title (en): STUDIES ON THE DUST IN THE PNEUMOCONIOTIC LUNG TISSUES Report 1: Direct Application of X-Ray Diffraction Method to the Large Section Specimens of Pneumoconiotic Lung
Authors (ja): 阿部 彰
Authors (en): Akira ABE & Tatsuo SANO
Authors (ja_kana): アベ アキラ
Authors etc: 佐野 辰雄
Authors etc (ja_kana): サノ タツオ
Keywords:                    
Issue Date: 10-Aug-1964 Literaturenumber: 640036 Number: 2
Magazinenumber: 1 Volume: 40 Issue: 8
Total No.: 0 Spage: 373 Epace: 407
URI: http://hdl.handle.net/11039/3117
DCMI: 労働科学−原著
code A: 7.4
numbe A: 職業病・職業性障害 − じん肺
Abstract: 著者らは、じん肺組織所見と肺内粉じんの性状の対比を目的とし、明確に部位、および組織所見を観察しえる大切片標本を使用し、各種鉱物性粉じんのX線回析法による定性分析を検討した。この方法は有機除去の操作を必要とせず、組織所見との対比がじゅうぶんにでき、かつ簡単に施行できる利点がある。この大切片標本X線回析法を用いて、急進珪肺、典型珪肺、非典型珪肺の各塊状巣の全資料にα-石英を認め、また粉じん巣融合部分にもα-石英が多数例に認められた。さらに黒鉛肺、滑石肺、蝋石肺の各種じん肺の粉じん巣の巨大融合部分には、おのおのの黒鉛、滑石の結晶を同定しえた。該方法は将来定量化も可能であり、じん肺病理学研究上有用な方法であると結論する。(図12・表12)(自抄)
Abstract(en): For the purpose to investigate pathohistological findings of pneumoconiotic tissue in relation to the property of dust in it, the present authors applied the X-ray diffraction method to large section specimens of the lungs aiming at first at the qualitative identification of dust. 1) Cutting off a discoidal piece of 24 mm in diameter from the large section specimen, the X-ray diffraction method was applied to the objective part of the piece placed at the centre. After repeated trials the standard error in determinations of the intensity of diffraction line was estimated at less than 2%, and it was revealed that, in case of α-quartz, not less than 0.2mg or 0.5 % of the weight of dried lung tissue could be detected by this method. The optimum conditions for the X-ray diffractometer seemed to be as follows: Cupper tube, nickel filter, 30KVP, 10mA, lo-lo-0.4mm in slit width, 800c/s of full scale count of recorder, 2 seconds of time constant. 2) α-quartz was detected in all of 21 cases of acutely developing silicosis and classical. silicosis, not only at the locus of silicotic massive fibrosis but also in the tissue bearing some nodules of about 4mm in diameter. In case of non-classical silicosis, α-quartz was detected in 3 cases out of 4, and diffraction lines of other than quartz were also noticed in these cases. 3) In 2 cases of talcosis, a good deal of talc was found in the coalescent dust foci and nectrotic substance in the cavity and also in some isolated nodules of 2-4mm in diameter. 4) Pyrophyllite was identified in coalescent dust foci of pyrophyllite pneumoconiosis, and it was found also, besides α-quartz, in the massive fibrosis in 2 cases of classical silicosis resulted by the service in pyrophyllite mine. 5) The diffraction line of graphite was evident at a black massive lesion of graphite pneumoconiosis, and also at the swarming small dust foci. 6) In 3 asbestosis cases with scattered irregular dust foci, crystalline was not found, though the rise of the background due to the increase of organic substance was noticed at the lesion with inflammatory complication. 7) In a coal miner’s pneumoconiosis case, α-quartz was detected at the massive fibrosis and the rise of background was striking. At the coalescent dust foci of 2 carbon lung cases, no crystalline was noticed but only the rise of background, seemingly due to abundant amorphous carbon. 8) In the examinations of 2 cases of diatomaceous earth pneumoconiosis, 3 of aluminium and alumina lung, one of pyrite pneumoconiosis and one of pyrite-cinder pneumoconiosis, any crystalline could not be found. The rise of background was noticed only in a case of aluminium lung. By the fluorescent X-ray analysis carried on with large section specimens, aluminium was identified in a case of aluminium lung and iron and copper in a case of pyrite and pyrite-cinder pneumoconiosis respectively. 9) The direct application of X-ray diffraction method to large section specimens seemed to be very hopeful in the pathological studies of pneumoconiosis in relation to the causal dust, and to have many good points in comparison with contemporary method, because it made possible the identification of dust property in the lesion without giving hurt to the specimen, without cumber some procedure of removing organic substances and because the quantitative analysis was likely possible.
Appears in Collections:1961-70

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